主要研究领域为微生物代谢工程与农业废弃物资源化利用，研究方向包括：（1）微生物种质资源创制创新：基于理性分子设计或非理性诱变和实验室进化策略创制工程菌株，实现秸秆转化微生物种质资源的改造、高通量筛选、评价和发酵过程工程放大优化等平台技术和方法的开发和应用；（2）代谢工程和合成生物学工具的开发和应用。以多基因代谢途径组装、CRISPR基因组编辑以及多组学数据整合分析为核心，开发生物合成底盘微生物；（3）农业废弃物的肥料化利用。近五年来，以第一或通讯作者（含并列）发表SCI论文16篇，授权发明专利1件（第一发明人）。现指导硕士生4名（含国际学生1名）。
Guiping Gong #*, Bo Wu #, Linpei Liu, Jianting Li, Qili Zhu, Mingxiong He*, Guoquan Hu, Metabolic engineering using acetate as a promising building block for the production of bio-based chemicals, Engineering Microbiology, 2022, 2: 100036 (Co-first author)
Panting Liu #, Bo Wu #, Mao Chen #, Yonghua Dai, Chao Song, Lingling Sun, Yuhuan Huang, Shenghao Li, Guoquan Hu, Mingxiong He*, Enhancing secretion of endoglucanase in Zymomonas mobilis by disturbing peptidoglycan synthesis, Applied and Environmental Microbiology, 2022, 88: e02161-21 (Co-first author)
Yonghua Dai #, Bo Wu#, Panting Liu, Mao Chen, Chao Song, Qiyu Gou, Renbin Liu, Yansheng Xu, Guoquan Hu, Mingxiong He*, Lowering whole cost for sugarcane-based ethanol production by engineered Zymomonas mobilis, GCB-Bioenergy, 13: 1894-1907 (Co-first author)
Ayesha Nisar, Xiangxu Gongye, Yuhuan Huang, Sawar Khan, Mao Chen, Bo Wu*, Mingxiong He, Genome-wide analyses of proteome and acetylome in Zymomonas mobilis under N2-fixing condition, Frontiers in Microbiology, 2021, 12: 740555 (Correspondent author)
Bo Wu #, Yan-Wei Wang #, Yong-Hua Dai, Chao Song, Qi-Li Zhu, Han Qin, Fu-Rong Tan, Cheng-Han Chen, Li-Chun Dai, Guo-Quan Hu, Ming-Xiong He*, Current status and future prospective of bio-ethanol industry in China, 2021, 145: 111079 (Co-first author)
Xiaojie Wang#, 1, Bo Wu#, 1, Xin Sui, Zhufeng Zhang, Tao Liu, Yingjun Li, Guoquan Hu, Mingxiong He*, Nan Peng*，CRISPR-mediated host genomic DNA damage is efficiently repaired through microhomology-mediated end joining in Zymomonas mobilis, Journal of Genetics and Genomics, 2021, 48: 115-122 (Co-first author)
Bo Wu #, Yan-Wei Wang #, Yong-Hua Dai, Chao Song, Qi-Li Zhu, Han Qin, Fu-Rong Tan, Cheng-Han Chen, Li-Chun Dai, Guo-Quan Hu, Ming-Xiong He*, Current status and future prospective of bio-ethanol industry in China, Renewable and Sustainable Energy Reviews, 2021, 145: 111079 (Co-first author)
Yan He #, Bo Wu #, Wei Xia, Kun-Yang Zhao, Yao Qin, Qiong Tan, Qin-Hui Yu, Pan-Ting Liu, Guo-Quan Hu, Ming-Xiong He*. Metabolic engineering of Zymomonas mobilis for ethylene production from straw hydrolysate, Applied Microbiology and Biotechnology, 2021, 105:1709–1720 (Co-first author)
Qinghui Yu#, Yuncheng Li#, Bo Wu*, Wei Hu* , Mingxiong He, Guoquan Hu Novel technologies for microbial strain improvement in food industry: Advances and prospects，Applied Microbiology and Biotechnology, 2020, 104:1517-1531 (Correspondent author)
Bo Wu #, Han Qin #, Yi-Wei Yang, Guo-Wei Duan, Chun-Yan Zhao, Shi-Hui Yang, Yan-Wei Wang, Qi-Li Zhu, Fu-Rong Tan, Guo-Quan Hu and Ming-Xiong He*, Engineered Zymomonas mobilis tolerant to acetic acid and low pH via multiplex atmospheric and room temperature plasma, Biotechnology for Biofuels, 2019，12：10 (Co-first author)
Weiting Wang #, Bo Wu #, Han Qin, Panting Liu, Yao Qin, Guowei Duan, Guoquan Hu, Mingxiong He*， Genome Shuffling Enhances Stress Tolerance of Zymomonas mobilis to Two-Inhibitors Biotechnology for Biofuels, 2019, 12:288 (Co-first author)
Guowei Duan #, Bo Wu #, Han Qin, Weiting Wang, Qiong Tan, Yonghua Dai, Yao Qin, Furong Tan, Guoquan Hu, and Mingxiong He*, Replacing water and nutrients for ethanol production by ARTP derived biogas slurry tolerant Zymomonas mobilis strain, Biotechnology for Biofuels, 2019, 12:124 (Co-first author)
Xue-jiao Tian, Ai-lian Jiang, Yan-qin Mao, Bo Wu*, Ming-xiong He, Wei Hu*, Ji-hong Chen, Wen-jian Li, Efficient L-lactic acid production from purified sweet sorghum juice coupling with soybean hydrolysate as nitrogen source by Lactobacillus thermophilus A69 strain. Journal of Chemical Technology & Biotechnology. 2019， 94:1752-1759 (Correspondent author)
Yang You#, Bo Wu #, Yi-Wei Yang; Yan-Wei Wang; Song Liu; Qi-Li Zhu; Han Qin; Fu-Rong Tan; Zhi-Yong Ruan; Ke-Dong Ma; Lin-Chun Dai; Min Zhang; Guo-Quan Hu; Ming-Xiong He, Replacing process water and nitrogen sources with biogas slurry during cellulosic ethanol production, Biotechnology for Biofuels, 2017, 10:236 (Co-first author)
Wang, Jing-Li #, Wu, Bo #, Qin, Han; You, Yang; Liu, Song; Shui, Zong-Xia; Tan, Fu-Rong; Wang, Yan-Wei; Zhu, Qi-Li; Li, Yan-Bin; Ruan, Zhi-Yong; Ma, Ke-Dong; Dai, Li-Chun; Hu, Guo-Quan; He, Ming-Xiong, Engineered Zymomonas mobilis for salt tolerance using EZ-Tn5-based transposon insertion mutagenesis system, Microbial Cell Factories, 2016, 15:101 (Co-first author)
Bo Wu, Dan Zheng, Zheng Zhou, Jing-Li Wang, Xiao-Lan He, Zheng-Wei Li, Hong-Nan Yang, Han Qin, Min Zhang, Guo-Quan Hu, Ming-Xiong He*, The enrichment of microbial community for accumulating polyhydroxyalkanoates using propionate-rich waste, Applied Biochemistry and Biotechnology, 2017, 182:755-768
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