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农业部沼气科学研究所

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导师简介

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何明雄,研究员,男,197811月生,理学博士,博士研究生导师,农业农村部沼气科学研究所生物质能技术研究中心主任。1995年毕业于四川大学生物工程系生物技术专业,理学学士;2008年毕业于四川大学生命科学院生物化学与分子生物学专业,理学博士。四川省省直机关青年联合会理事、四川省科技青年联合会理事、Biotechnology for BiofuelsSCI杂志审稿专家。2014年入选“第十一批四川省学术和技术带头人后备人选”;2015年获第十三届四川省青年科技奖;2016年入选中国农业科学院“科研英才培育工程计划”;2017年入选中国农业科学院“农科英才”计划。

主要从事微生物代谢工程与生物质转化等研究工作。先后主持或参加国家自然科学基金、四川省杰出青年科学基金、四川省科技支撑计划、国家水体污染控制与治理科技重大专项、国家科技支撑计划、公益性行业科研专项等多项课题的研究工作。共计在国内外学术期刊发表论文80余篇。以第一或通讯作者在Biotechnol BiofuelsApp Microbiol BiotechnolBioresourceTechnolMicrobial Cell FactoriesCarbohydrate PolymersSCI期刊发表论文27篇,其中IF>3.0的论文14篇;其它作者SCI论文25篇;第一作者或通讯作者中文核心刊物17篇。发表的论文被引用700余次;获授权国家发明专利3项;成果鉴定1项。培养研究生8名,指导培养的研究生获“中国农业科学院优秀硕士学位论文”及“研究生国家奖学金”等荣誉。

目前在研项目包括:主持国家自然科学基金面上项目、四川省杰出青年基金、中国农业科学院基础研究引导计划等项目;参加中国农业科学院农业科技创新工程专项及公益性行业(农业)科研专项等项目。

代表性论文:

1.He MX*, Wu B, Shui ZX, Hu QC, Wang WG, Tan FR, Tang XY, Zhu QL, Pan K, Li Q et al: Transcriptome profiling of Zymomonas mobilis under ethanol stress. Biotechnology for Biofuels 2012, 5:75.

2.MX He*, Bo Wu, Han Qin, Zhi-yong Ruan, Fu-rong Tan, Jing-li Wang, Zong-xia Shui, Li-chun Dai, Qi-li Zhu, Ke Pan, Xiao-yu Tang, Wen-guo Wang, Qi-chun Hu. Zymomonas mobilis: A Novel Platform for Future Biorefineries. Biotechnology for Biofuels 2014, 7(101): 1-15

3.Yang You, Bo Wu, Yi-Wei Yang, Yan-Wei Wang, Song Liu, Qi-Li Zhu, Han Qin, Fu-Rong Tan, Zhi-Yong Ruan, Ke-Dong Ma, Li-Chun Dai, Min Zhang, Guo-Quan Hua and Ming-Xiong He*. Replacing Process Water and Nitrogen Source with Biogas Slurry During of Cellulosic Ethanol Production. Biotechnology for Biofuels,2017, 10:236

4.Kedong Ma*, Mingxiong He, Huiyan You, Liwei Pan, Guoquan Hu, Yubo Cui and Toshinari Maeda. Efficient (R,R)-2,3-butanediol production from corn stover hydrolysate in cell recycle continuous fermentation strategy using Paenibacillus polymyxa. Chemical Engineering Journal, 2018,332, 361-369(并列第一)

5.Ming-xiong He*, Jing-li Wang, Han Qin, Zong-xia Shui, Qi-li Zhu, Bo Wu, Fu-rong Tan, Ke Pan, Qi-chun Hu, Li-chun Dai, Wen-guo Wang, Xiao-yu Tang, Guo Quan Hu*: Bamboo: A new source of carbohydrate for biorefinery. Carbohydrate Polymers 2014, 111:645-654

6.Kedong Ma, Zhiyong Ruan, Zongxia Shui, Yanwei Wang, Guoquan Hu, Mingxiong He*. Open fermentative production of fuel ethanol from food waste by an acid-tolerant mutant strain of Zymomonas mobilis. Bioresource Technology, 2016, 203:295-302

7.Kedong Ma, Guoquan Hu, Liwei Pan, Zichao Wang, Yi Zhou,Yanwei Wang, Zhiyong Ruan, Mingxiong He*. Highly efficient production of optically pure L-lactic acid from corn stover hydrolysate by thermophilic Bacillus coagulans. Bioresource Technology,2016, 219: 114–122

8.He MX*, WU B, Shui ZX, Hu QC, Wang WG, Tan FR, Tang XY, Zhu QL, Pan K, Li Q et al: Transcriptome profiling of Zymomonas mobilis under furfural stress. Appl Microbiol Biotechnol 2012, 95:189-199

9.Zong-Xia Shui, Han Qin, Bo Wu, Zhi-yong Ruan, Lu-shang Wang, Fu-Rong Tan, Jing-Li Wang, Xiao-Yu Tang, Li-Chun Dai, Guo-Quan Hu*, Ming-Xiong He*. Adaptive laboratory Evolution of Ethanologenic Zymomonas mobilis Strain Tolerant to Furfural and Acetic-acid Inhibitors. Appl Microbiol Biotechnol 2015, 99:5739–5748

10.Fu-Rong Tan, Li-Chun Dai, Bo Wu, Han Qin, Zong-Xia Shui, Jing-Li Wang, Qi-Li Zhu, Qi-Chun Hu, Zhi-Yong Ruan, Ming-Xiong He*. Improving furfural tolerance of Zymomonas mobilis by rewiring a sigma factor RpoD protein. Appl Microbiol Biotechnol 2015, 99:5363-5371

11.Furong Tan, Bo Wu, Lichun Dai, Han Qin, Zongxia Shui, Jingli Wang, Qili Zhu,  Guoquan Hu*, Mingxiong He*.Using Global Transcription Machinery Engineering (gTME) to Improve Ethanol Tolerance of Zymomonas mobilis. Microbial Cell Factories, 2016,15:4

12.Jing-Li Wang, Bo Wu, Han Qin, Yang you, Song Liu, Zong-Xia Shui, Fu-Rong Tan,  Yan-Wei Wang, Qi-Li Zhu, Yan-Bin Li, Zhi-Yong Ruan, Ke-Dong Ma, Li-Chun Dai, Guo-Quan Hu, Ming-Xiong He*. Engineered Zymomonas mobilis for Salt Tolerance Using EZ-Tn5-based Transposon Insertion Mutagenesis System. Microbial Cell Factories, 2016, 15:101

13.Kedong Ma*, Mingxiong He, Huiyan You, Liwei Pan, Guoquan Hu, Yubo Cui and Toshinari Maeda. Enhanced fuel ethanol production from rice straw hydrolysate by an inhibitor-tolerant mutant strain of Scheffersomyces stipitis. RSC Advances, 2017, 7, 31180

14.Yang You, Song Liu, Bo Wu, Yan-Wei Wang, Qi-Li Zhu, Han Qin, Fu-Rong Tan, Zhi-Yong Ruan, Ke-Dong Ma, Li-Chun Dai, Min Zhang, Guo-Quan Hu and Ming-Xiong He*. Bio-ethanol Production by Zymomonas mobilis using Pretreated Dairy Manure as Carbon and Nitrogen Source.  RSC Advances, 2017, 7, 3768–3779

 

联系地址:四川省成都市人民南路四段13号,610041,农业农村部沼气科学研究所

电话:028-85242281

E-mail: hemingxiong@caas.cn